pentobarbital will reduce the extent or result of exemestane by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. For patients obtaining exemestane with a potent CYP3A4 inducer the advisable dose of exemestane is 50 mg day-to-day following a food.pentobarbital will lower the level or outcome of bexarotene by impacting hepa